The San Francisco 49ers are preparing to face the Los Angeles Rams in a crucial Thursday Night Football matchup. With a key trio of injuries affecting the team, fans are asking: Will Brock Purdy suit up and lead the offense, or will the 49ers have to rely on backup Mac Jones?
Will Brock Purdy play against the Rams tonight?
Brock Purdy is ruled out due to a toe injury. He won’t be available for the game, which is a significant blow for the 49ers’ offense. Backup Mac Jones is expected to start under center, making this his first start with the team in a live game situation.Purdy’s absence shifts the responsibility to Mac Jones, who will have to manage the offense and maintain the rhythm established by the 49ers’ starting lineup. Fans should expect adjustments in play-calling and potentially a simplified game plan to accommodate the change at quarterback.
Other key injury updates for the 49ers
- WR Jauan Jennings — OUT (Ankle & Ribs)
Jennings will not play against the Rams. He’s been a reliable target, and his absence puts more pressure on the remaining receivers to step up. - WR Ricky Pearsall — OUT (Knee)
Pearsall is also ruled out, reducing depth in the wide receiver room and forcing the 49ers to lean on backups or rotate additional personnel into the lineup.
Final injury report: 49ers vs. Rams game status
San Francisco 49ers
- QB Brock Purdy — OUT
- WR Jauan Jennings — OUT
- WR Ricky Pearsall — OUT
- QB Mac Jones — Active, starting
Los Angeles RamsDoubtful:
- T Rob Havenstein (Ankle) – Might miss the game, could affect OL protection.
- TE Tyler Higbee (Hip) – May not play, backup TEs likely to see more snaps.
Full Participation:G Steve Avila (Ankle) – Expected to play.TE Colby Parkinson (Shoulder) – Active.S Kamren Kinchens (Shoulder) – Active.
49ers vs. Rams game details and how to watch
- Date: Thursday, October 2, 2025
- Time: 8:15 PM ET / 5:15 PM PT
- Venue:
SoFi Stadium , Inglewood, CA - TV/Stream: The game will be broadcast nationally on
Prime Video and locally in Los Angeles on FOX 11/KTTV. You can also stream the game on NFL+.
Brock Purdy’s impact on the 49ers’ offense
Brock Purdy’s absence is huge not just because he’s the starter, but because of the leadership and timing he brings to the offense. Mac Jones will now have to manage the game, and the receiving corps will have to adjust with Jennings and Pearsall out. Rookie receivers or secondary targets may see more snaps, and the team will likely rely more heavily on the running game to balance the offense.49ers fans will be watching closely to see how Jones performs and whether the team can maintain momentum without their starting QB. Purdy’s return will be key for keeping the 49ers’ playoff hopes on track, but for Thursday night, all eyes are on Mac Jones and how the offense adapts to these injuries.Also read – Russell Wilson caught looking ‘disgusted’ during Jaxson Dart’s locker room speech, and fans are losing it
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